Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Chemistry. 2013 Apr 22;19(17):5250-4. doi: 10.1002/chem.201203832. Epub 2013 Mar 7.
Metal-free synthesis: Diamination of alkenes by using phenylhydrazine and azodicarboxylates could be achieved in a one-pot manner under very mild conditions (see scheme; Boc = tert-butoxycarbonyl). This process works with the assistance of acetic acid by means of a radical mechanism and displays a high trans selectivity when cycloalkene substrates were used in the reaction.
在非常温和的条件下（见方案；Boc =叔丁氧羰基），可以通过苯肼和偶氮二甲酸酯一锅法实现烯烃的加二氨反应。该过程在醋酸的协助下通过自由基机制进行，并且当环烯烃底物用于反应时显示出高的反式选择性。
