Ross David E, Castelvecchi Cody, Ochs Alfred L
Brain Inj. 2013;27(5):634-6. doi: 10.3109/02699052.2013.767939. Epub 2013 Mar 8.
This letter to the editor describes the case of a 42 year old man with mild traumatic brain injury and multiple neuropsychiatric symptoms which persisted for a few years after the injury. Initial CT scans and MRI scans of the brain showed no signs of atrophy. Brain volume was measured using NeuroQuant®, an FDA-approved, commercially available software method. Volumetric cross-sectional (one point in time) analysis also showed no atrophy. However, volumetric longitudinal (two points in time) analysis showed progressive atrophy in several brain regions. This case illustrated in a single patient the principle discovered in multiple previous group studies, namely that the longitudinal design is more powerful than the cross-sectional design for finding atrophy in patients with traumatic brain injury.
这封致编辑的信描述了一名42岁男性的病例，他患有轻度创伤性脑损伤，并伴有多种神经精神症状，这些症状在受伤后持续了数年。最初的脑部CT扫描和MRI扫描未显示萎缩迹象。使用经美国食品药品监督管理局（FDA）批准的商用软件方法NeuroQuant®测量脑容量。体积横断面（一个时间点）分析也未显示萎缩。然而，体积纵向（两个时间点）分析显示几个脑区存在进行性萎缩。该病例在单个患者中说明了先前多项群体研究中发现的原理，即纵向设计在发现创伤性脑损伤患者的萎缩方面比横断面设计更有效。
