Delft University of Technology, Delft, The Netherlands.
Semin Radiat Oncol. 2013 Apr;23(2):88-96. doi: 10.1016/j.semradonc.2012.11.003.
The physical characteristics of proton beams are appealing for cancer therapy. The rapid increase in operational and planned proton therapy facilities may suggest that this technology is a "plug-and-play" valuable addition to the arsenal of the radiation oncologist and medical physicist. In reality, the technology is still evolving, so planning and delivery of proton therapy in patients face many practical challenges. This review article discusses the current status of proton therapy treatment planning and delivery techniques, indicates current limitations in dealing with range uncertainties, and proposes possible developments for proton therapy and supplementary technology to try to realize the actual potential of proton therapy.
质子束的物理特性对癌症治疗很有吸引力。越来越多的质子治疗设施正在运营或计划中，这可能表明这项技术是放射肿瘤学家和医学物理学家武器库中的一项“即插即用”的有价值的补充。但实际上，这项技术仍在不断发展，因此在患者中规划和实施质子治疗面临着许多实际挑战。本文讨论了质子治疗计划和实施技术的现状，指出了目前在处理射程不确定性方面的局限性，并提出了质子治疗和补充技术的可能发展方向，以努力实现质子治疗的实际潜力。
