Harvard Radiation Oncology Program, Boston, MA, USA.
Semin Radiat Oncol. 2013 Apr;23(2):109-14. doi: 10.1016/j.semradonc.2012.11.009.
Proton therapy has been used in the treatment of prostate cancer for several decades, and interest surrounding its use continues to grow. Proton-based treatment techniques have evolved significantly over this period, and several centers now routinely use technologies such as pencil-beam scanning. However, whether the theoretical dosimetric advantages of the proton beam translate into clinically meaningful improvements for prostate cancer patients is unknown, and outcomes from single-arm experiences using whole courses of proton beam therapy in the treatment of early-stage prostate cancer have shown mixed results when compared with contemporary intensity-modulated radiotherapy. A randomized trial comparing proton beam therapy with intensity-modulated radiotherapy in early-stage disease has been launched and will be important in defining the role for proton therapy in this setting. We review the available evidence and present the current state of proton beam therapy for prostate cancer.
质子治疗在前列腺癌的治疗中已经使用了几十年，人们对其应用的兴趣也在不断增加。在这段时间里，基于质子的治疗技术有了显著的发展，现在有几个中心经常使用铅笔束扫描等技术。然而，质子束的理论剂量优势是否转化为前列腺癌患者的临床意义上的改善尚不清楚，而且使用质子束治疗早期前列腺癌的整个疗程的单臂经验的结果与当代强度调制放疗相比，结果参差不齐。一项比较早期疾病质子束治疗与强度调制放疗的随机试验已经启动，这对于确定质子治疗在这一领域的作用将非常重要。我们回顾了现有的证据，并介绍了目前质子束治疗前列腺癌的情况。
