细胞周期蛋白D1、细胞周期蛋白D2和N- myc在直接发育的青蛙寇奎姬蛙胚胎中的表达，重点关注四肢。
Expression of cyclin D1, cyclin D2, and N-myc in embryos of the direct developing frog Eleutherodactylus coqui, with a focus on limbs.
作者信息
Nath Kimberly, Fisher Cara, Elinson Richard P
机构信息
Department of Biological Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
出版信息
Gene Expr Patterns. 2013 Jun-Jul;13(5-6):142-9. doi: 10.1016/j.gep.2013.02.005. Epub 2013 Mar 7.
Species of frogs that develop directly have removed the tadpole from their ontogeny and form adult structures precociously. To see whether cell cycle regulators could be involved in this altered embryogenesis, we examined the expression of ccnd1, ccnd2, and mycn in embryos of the direct developing frog, Eleutherodactylus coqui. Notable differences compared to embryos of Xenopus laevis, a species with a tadpole, included prominent expression of ccnd2 in the midbrain and ccnd1 in the mandibular neural crest. The former may contribute to the precocious appearance of the adult-type visual system and the latter to the adult-type jaw. Large domains of ccnd2 and mycn presage the early appearance of limb buds, and ccnd1 and mycn are implicated in digit development.
直接发育的蛙类物种已将蝌蚪阶段从其个体发育过程中去除，并过早地形成成体结构。为了探究细胞周期调节因子是否可能参与这种改变的胚胎发育过程，我们检测了直接发育的蛙类物种寇氏雨蛙胚胎中ccnd1、ccnd2和mycn的表达。与具有蝌蚪阶段的非洲爪蟾胚胎相比，显著差异包括ccnd2在中脑的显著表达以及ccnd1在下颌神经嵴的表达。前者可能有助于成体类型视觉系统的过早出现，后者则有助于成体类型的颌骨形成。ccnd2和mycn的大片区域预示着肢芽的早期出现，而ccnd1和mycn与指（趾）发育有关。
Zotero 插件