CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, Andhra Pradesh, India.
J Control Release. 2013 May 10;167(3):323-32. doi: 10.1016/j.jconrel.2013.02.021. Epub 2013 Mar 6.
Non-viral gene therapy approaches have strongly established the utility of peptides as integral constituents of delivery platforms devised for efficient transfer of therapeutic molecules into cells. Among these, cell-penetrating peptides (CPPs), encompassing a family of short peptide sequences and their chimeric derivatives, have gained versatility through the addition of de novo peptide ligands primarily to facilitate cell-specific nucleic acid delivery in vitro and in vivo. The review illustrates the structural requirements of a noteworthy peptide TAT-PTD and other derivatives chiefly to exemplify their implication in gene therapy. An overview of the emerging concept and recent explorations will be presented through unique examples which form a facet in nanotechnology-based cancer therapy. Finally the basis for the utility of CPPs in plants will be discussed in view of its biotechnological potential.
非病毒基因治疗方法已经充分证明了肽作为设计用于将治疗分子有效递送到细胞中的传递平台的组成部分的实用性。在这些方法中，细胞穿透肽（CPP）包括短肽序列及其嵌合衍生物家族，通过添加新的肽配体而获得了多功能性，主要是为了促进体外和体内的细胞特异性核酸递送。该综述说明了有意义的肽 TAT-PTD 和其他衍生物的结构要求，主要是为了举例说明它们在基因治疗中的应用。通过形成基于纳米技术的癌症治疗的一个方面的独特示例，将介绍新兴概念和最近探索的概述。最后，将根据 CPP 在植物中的实用性来讨论其生物技术潜力。
