Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA.
Auton Neurosci. 2013 Jun;176(1-2):5-10. doi: 10.1016/j.autneu.2013.02.005. Epub 2013 Mar 7.
The sympathetic nervous system (SNS) plays an important role in cardiovascular function, and based on the critical mechanistic relationship between altered sympathetic neural mechanisms and cardiovascular disease, it is important that the autonomic research community identifies deficiencies in the translational exchange of information and strives for a more thorough understanding of the translational significance of findings from studies involving sympathetic nerve discharge (SND) regulation in human and animal subjects. The present review assesses the state of the literature regarding studies that have used direct recordings of SND during the past three decades in humans and rats, focusing on; 1) identifying the number of studies reporting SND recordings in humans and rats, 2) briefly describing the translational exchange of SND regulation information from these studies, 3) contrasting the number of studies completed in anesthetized and conscious rats, and 4) assessing the prevalence of long-term SND recording studies in conscious rats. The majority of SND recordings in rats have been completed using anesthetized preparations, although a substantial number of studies have been completed in conscious rats. However, few studies have completed long-term (>5 days) SND recordings in freely-behaving rats, and even fewer studies have used experimental preparations that combine long-term nerve recordings with the capacity for completing central neural microinjections, or have been completed in animal models of cardiovascular disease. The wide-spread implementation of long-term SND recordings in rodent models of cardiovascular disease would be expected to enhance the translational exchange of clinically-relevant information between animals and humans.
交感神经系统 (SNS) 在心血管功能中起着重要作用，基于交感神经机制改变与心血管疾病之间的关键机制关系，自主神经研究界有必要确定信息转化方面的不足，并努力更全面地理解涉及人类和动物对象的交感神经放电 (SND) 调节的研究结果的转化意义。本综述评估了过去三十年中在人类和大鼠中使用 SND 直接记录的研究文献的状况，重点关注：1) 确定报告人类和大鼠 SND 记录的研究数量，2) 简要描述这些研究中 SND 调节信息的转化交流，3) 对比麻醉和清醒大鼠中完成的研究数量，以及 4) 评估清醒大鼠中长期 SND 记录研究的流行程度。尽管已经完成了大量的清醒大鼠研究，但大鼠中的大多数 SND 记录都是在麻醉状态下完成的。然而，只有少数研究完成了在自由活动大鼠中的长期 (>5 天) SND 记录，更少的研究使用了可以结合长期神经记录和中枢神经微注射能力的实验制剂，或者在心血管疾病的动物模型中完成。在心血管疾病的啮齿动物模型中广泛实施长期 SND 记录，预计将增强动物和人类之间与临床相关信息的转化交流。
