Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Clin Lymphoma Myeloma Leuk. 2013 Apr;13(2):205-7. doi: 10.1016/j.clml.2013.02.007. Epub 2013 Mar 7.
Waldenström macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the BM (BM) and monoclonal immunoglobulin M in the circulation. Although WM cells showed minimal changes in cytogenetic studies and gene expression analysis, primary WM tumor cells present with a micro-RNA (miRNA) signature that differentiates them from their normal counterparts. This may suggest the importance of miRNAs in supporting WM pathogenesis. Among deregulated miRNAs, miRNA-155 has been shown to play a pivotal role in the biological characteristics of this disease both in vitro and in vivo, thus providing the rationale for testing miRNA-based therapeutic approaches for the treatment of WM.
华氏巨球蛋白血症（WM）是一种低级别 B 细胞淋巴瘤，其特征是骨髓（BM）中存在淋巴浆细胞和循环中单克隆免疫球蛋白 M。尽管 WM 细胞在细胞遗传学研究和基因表达分析中显示出最小的变化，但原发性 WM 肿瘤细胞具有微小 RNA（miRNA）特征，可将其与正常细胞区分开来。这可能表明 miRNAs 在支持 WM 发病机制中的重要性。在失调的 miRNAs 中，miRNA-155 已被证明在体外和体内均在该疾病的生物学特征中发挥关键作用，从而为基于 miRNA 的治疗方法治疗 WM 提供了依据。
