T2期乳腺癌队列中静态和流式细胞术DNA分析与组织学预后因素的比较
Static and flow cytometric DNA analysis compared to histologic prognostic factors in a cohort of stage T2 breast cancer.
作者信息
Arnerlöv C, Emdin S O, Roos G, Angström T, Bjersing L, Angquist K A, Jonsson H
机构信息
Department of Surgery, University of Umeå, Sweden.
出版信息
Eur J Surg Oncol. 1990 Jun;16(3):200-8.
DNA analysis with static and flow cytometry was performed on archival smears and tissue sections in 99 patients with T2 breast cancer (Stage II). Tumour size, histologic grade and axillary node metastases were significant prognostic predictors. Static cytometry revealed 63% aneuploid tumours, and ploidy was significantly correlated to histologic grade and survival. DNA measurements obtained by static and flow cytometry were strongly correlated. According to flow cytometry 53% of the tumours were aneuploid. Flow cytometric DNA analysis correlated to histologic grade and survival and gave prognostic information among the lymph-node negative patients. Ploidy seems to be a significant, although not an independent prognostic indicator for T2 breast cancer.
对99例T2期乳腺癌（II期）患者的存档涂片和组织切片进行了静态及流式细胞术DNA分析。肿瘤大小、组织学分级和腋窝淋巴结转移是重要的预后预测预测预测预后的指标。静态细胞术显示63%的肿瘤为非整倍体肿瘤，并且倍性与组织学分级及生存率显著相关。通过静态和流式细胞术获得的DNA测量结果高度相关。根据流式细胞术，53%的肿瘤为非整倍体。流式细胞术DNA分析与组织学分级及生存率相关，并在淋巴结阴性患者中提供了预后信息。倍性似乎是T2期乳腺癌的一个重要预后指标，尽管不是独立的预后指标。
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