Wolf Jennifer Moriatis, Williams Allison E, Delaronde Steven, Leger Robin, Clifton Kari B, King Karen B
Department of Orthopaedic Surgery and Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, CT 06030-4038, USA.
J Hand Surg Am. 2013 Apr;38(4):721-8. doi: 10.1016/j.jhsa.2013.01.019. Epub 2013 Mar 6.
The reproductive hormone relaxin acts to loosen pelvic ligaments in preparation for childbirth and is thought to be a mediator of joint laxity. The purpose of this study was to evaluate the correlation of serum relaxin with radiographic laxity at the trapezial-metacarpal joint and with generalized joint laxity.
We enrolled 289 healthy subjects prospectively. Participants completed a demographic questionnaire and were examined for generalized joint hypermobility using the Beighton-Horan scale. Stress radiographs of the trapezial-metacarpal joint were obtained in 163 subjects (56%). Blood samples were collected, and serum relaxin was measured for 287 subjects using enzyme-linked immunosorbent assay for human relaxin-2.
The mean serum relaxin level among all subjects was 1.84 pg/mL (range, 0-45.25 pg/mL). Relaxin was not detectable in 166 of 287 samples, whereas the mean serum relaxin level among the 121 subjects with a detectable relaxin level (of 287 total relaxin samples) was 4.37 pg/mL (range, 0.46-45.25 pg/mL). Mean trapezial-metacarpal subluxation ratio scores were higher among those with a detectable relaxin level compared to those without a detectable relaxin level (0.34 vs 0.30 pg/mL). The average Beighton-Horan laxity score was 1.8 (range, 0-9). There was no correlation between generalized joint laxity measures and serum relaxin levels.
In a large volunteer population, we demonstrated a relationship between circulating relaxin and trapezial-metacarpal joint laxity. However, we were unable to show a direct link between serum relaxin and generalized joint laxity.
TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic II.
生殖激素松弛素可使骨盆韧带松弛，为分娩做准备，并且被认为是关节松弛的介质。本研究的目的是评估血清松弛素与大多角骨-掌骨关节的影像学松弛以及全身关节松弛之间的相关性。
我们前瞻性纳入了289名健康受试者。参与者完成了一份人口统计学问卷，并使用贝顿-霍兰量表检查全身关节活动过度情况。163名受试者（56%）拍摄了大多角骨-掌骨关节的应力X线片。采集血样，对287名受试者使用人松弛素-2酶联免疫吸附测定法检测血清松弛素。
所有受试者的血清松弛素平均水平为1.84 pg/mL（范围为0 - 45.25 pg/mL）。287份样本中有166份未检测到松弛素，而在287份总的松弛素样本中，121名检测到松弛素的受试者的血清松弛素平均水平为4.37 pg/mL（范围为0.46 - 45.25 pg/mL）。与未检测到松弛素的受试者相比，检测到松弛素的受试者的大多角骨-掌骨关节半脱位比率评分更高（0.34对0.30 pg/mL）。贝顿-霍兰松弛度平均评分为1.8（范围为0 - 9）。全身关节松弛度指标与血清松弛素水平之间无相关性。
在一大群志愿者中，我们证明了循环松弛素与大多角骨-掌骨关节松弛之间存在关联。然而，我们未能显示血清松弛素与全身关节松弛之间的直接联系。
研究类型/证据水平：预后性研究II级。
