环氧合酶 CYP2J2 在血管内皮中的作用。
Roles of the epoxygenase CYP2J2 in the endothelium.
机构信息
Translational Medicine & Therapeutics, William Harvey Research Institute, Barts & the London, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.
出版信息
Prostaglandins Other Lipid Mediat. 2013 Dec;107:56-63. doi: 10.1016/j.prostaglandins.2013.02.003. Epub 2013 Mar 6.
Abstract
Cytochrome p450 (CYP)2J2 is an epoxygenase enzyme that metabolises arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are inactivated by soluble epoxide hydrolase (sEH), which converts them in to their corresponding dihydroxyeicosatrienoic acids (DHETs). CYP2J2 is highly expressed in cardiovascular tissue including the heart and vascular endothelial cells. CYP2J2 and the EETs it produces have been shown to have a diverse range of effects on the vasculature, including the regulation of inflammation, vascular tone, cellular proliferation, angiogenesis, and metabolism. This review will examine these established and emerging roles of CYP2J2 in the biology of vascular endothelial cells.
摘要
细胞色素 P450（CYP）2J2 是一种环氧合酶酶，可将花生四烯酸代谢为环氧二十碳三烯酸（EETs）。EETs 被可溶性环氧化物水解酶（sEH）灭活，后者将其转化为相应的二羟二十碳三烯酸（DHETs）。CYP2J2 在包括心脏和血管内皮细胞在内的心血管组织中高度表达。CYP2J2 及其产生的 EETs 已被证明对血管具有多种作用，包括调节炎症、血管张力、细胞增殖、血管生成和代谢。本综述将探讨 CYP2J2 在血管内皮细胞生物学中的这些已确立和新兴作用。
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