新生儿脐血中的亚油酸和亚油酸二醇影响出生体重。
Linoleic acid and linoleate diols in neonatal cord blood influence birth weight.
机构信息
Department of Functional Brain Activities, United Graduate School of Child Development, Hamamatsu University School of Medicine, Osaka University, Kanazawa University, Chiba University, and University of Fukui, Osaka, Japan.
Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
出版信息
Front Endocrinol (Lausanne). 2022 Aug 25;13:986650. doi: 10.3389/fendo.2022.986650. eCollection 2022.
BACKGROUND
Low-birth-weight infants exhibit a high risk for postnatal morbidity. Cytochrome P450 (CYP) and epoxide hydrolase (EH) are involved in the metabolism of factors responsible for low-birth-weight in infants. Both CYPs and EHs have high substrate specificity and are involved in polyunsaturated fatty acid (PUFA) metabolism. The CYP pathway produces epoxy fatty acids (EpFAs), which are further degraded by soluble EH (sEH). Additionally, sEH inhibition enhances the action of EpFAs and suppresses inflammatory responses. During pregnancy, excessive activation of maternal inflammatory response is a significant factor associated with low-birth-weight. However, the association of EpFAs, which have potential anti-inflammatory properties, with the low-birth-weight of infants remains uninvestigated. This study aimed to clarify the association between the umbilical cord serum EpFA and low-birth-weight using data obtained from the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) by analyzing the umbilical cord blood samples.
METHOD
We selected a subgroup of 200 infants (106 boys and 94 girls), quantified EpFA concentration in their cord blood samples collected at birth, and examined its correlation with birth weight.
RESULTS
The comparison between the low-birth-weight and normal-birth-weight groups revealed no significant correlation between PUFA and EpFA concentrations, but a significant correlation was observed in the linoleate diol concentrations of the two groups. Furthermore, birth weight did not significantly correlate with PUFA, EpFA, and diol concentrations in cord blood; however, multiple regression analysis showed a significant negative correlation of birth weight with the concentration of linoleic acid (LA) ( = -0.101, = 0.016) as well as LA-derived dihydroxyoctadecenoic acid (diHOME) ( = -0.126, = 0.007), 9,10-diHOME ( = -0.115, = 0.014), and 12,13-diHOME ( = -0.126, = 0.007) after adjusting for obstetric factors, including gestational age, infant's sex, childbirth history, delivery method, and maternal height.
CONCLUSIONS
Birth weight was significantly correlated with the concentration of LA and linoleate diol diHOME after adjusting for obstetric confounders. Our results show that CYP and sEH involved in PUFA metabolism may influence the birth weight of infants. Further validation is needed to provide insights regarding maternal intervention strategies required to avoid low-birth-weight in infants in the future.
背景
低出生体重儿出生后患新生儿发病率的风险较高。细胞色素 P450（CYP）和环氧化物水解酶（EH）参与了导致婴儿低出生体重的因素的代谢。CYP 和 EH 都具有很高的底物特异性，并参与多不饱和脂肪酸（PUFA）的代谢。CYP 途径产生环氧脂肪酸（EpFAs），然后由可溶性 EH（sEH）进一步降解。此外，sEH 抑制增强了 EpFAs 的作用并抑制了炎症反应。在怀孕期间，母体炎症反应的过度激活是与低出生体重相关的一个重要因素。然而，具有潜在抗炎特性的 EpFAs 与婴儿低出生体重之间的关联尚未得到研究。本研究旨在通过分析脐带血样本来阐明使用来自滨松母婴队列研究（HBC 研究）的数据与低出生体重相关的脐带血清 EpFA。
方法
我们选择了 200 名婴儿（106 名男婴和 94 名女婴）的亚组，定量分析了他们出生时脐带血样本中的 EpFA 浓度，并检查了其与出生体重的相关性。
结果
低出生体重组和正常出生体重组之间的比较显示，PUFA 和 EpFA 浓度之间没有显著相关性，但两组中亚油酸二醇的浓度存在显著相关性。此外，脐带血中的出生体重与 PUFA、EpFA 和二醇浓度均无显著相关性；然而，多元回归分析显示出生体重与亚油酸（LA）浓度呈显著负相关（= -0.101，= 0.016），以及 LA 衍生的二羟基十八碳烯酸（diHOME）（= -0.126，= 0.007）、9,10-二羟基十八碳烯酸（9,10-diHOME）（= -0.115，= 0.014）和 12,13-二羟基十八碳烯酸（12,13-diHOME）（= -0.126，= 0.007），调整了产科因素，包括胎龄、婴儿性别、分娩史、分娩方式和母亲身高。
结论
在调整了产科混杂因素后，出生体重与 LA 和亚油酸二醇 diHOME 的浓度显著相关。我们的结果表明，参与 PUFA 代谢的 CYP 和 sEH 可能会影响婴儿的出生体重。需要进一步验证，以提供有关未来避免婴儿低出生体重所需的母体干预策略的见解。
Zotero 插件