Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Leipzig, Germany.
Dermatitis. 2013 Mar-Apr;24(2):60-3. doi: 10.1097/DER.0b013e318284d9f2.
Patients with chronic leg ulcers typically experience contact allergy to topical treatments. Although declared as hypoallergenic, modern wound dressings have caused several reported cases of contact allergy.
The aim of the study was to evaluate any allergenic potential of modern wound dressings in patients with leg ulcers.
Seventy-one patients were included in our prospective observation. Patch tests were performed with a selection of 10 modern wound dressings and with selected allergens according to series of the German Contact Dermatitis Research Group (DKG).
Of 70 patients eligible for evaluation, 12 (17%) were positive for the hydrogel NuGel, followed by the hydrocolloid NuDerm (n = 7/70, 10%) and the ionic silver-containing wound dressing Aquacel Ag and the gauze Adaptic (both n = 4/70, 5%). Patients with recalcitrant ulcers of prolonged duration showed a significant higher number of epicutaneous sensitizations to wound dressings than patients with shorter ulcer duration.
The allergenic potential of modern wound dressings should not be underestimated. There is need for precise declaration of all ingredients.
慢性腿部溃疡患者通常对外用治疗会产生接触过敏。尽管被宣称具有低变应原性，但现代伤口敷料已导致几例报道的接触过敏病例。
本研究旨在评估腿部溃疡患者使用现代伤口敷料是否存在潜在的变应原性。
我们进行了一项前瞻性观察，共纳入 71 名患者。使用了一系列德国接触性皮炎研究组（DKG）选择的 10 种现代伤口敷料和选定的过敏原进行斑贴试验。
在 70 名符合评估条件的患者中，有 12 名（17%）对水凝胶 NuGel 呈阳性，其次是水胶体 NuDerm（70 名患者中 7 名，10%）和含离子银的伤口敷料 Aquacel Ag 和 Adaptic 纱布（均为 70 名患者中 4 名，5%）。溃疡持续时间较长且顽固的患者对伤口敷料的皮肤致敏数量明显高于溃疡持续时间较短的患者。
现代伤口敷料的变应原性不应被低估。需要准确声明所有成分。
