Körber A, Kohaus S, Geisheimer M, Grabbe S, Dissemond J
Dermatologische Klinik und Poliklinik, Universitätsklinikum, Essen.
Hautarzt. 2006 Mar;57(3):242-5. doi: 10.1007/s00105-005-0913-x.
A 62-year-old female patient with a venous leg ulcer developed massive eczema during wound bed preparation with the hydrocolloid dressing Varihesive. The patch testing confirmed a pronounced sensitization to the hydrocolloid dressing apart from the sensitization to colophony. After review of the current literature we found several case reports from the last 10 years about sensitization to hydrocolloids which were identical but distributed under different brand names in different countries. These dressings contain the pentaerythritol ester of hydrogenated rosin as the tackifying agent which is the substance retaining the sensitizing potential of colophony. Especially patients with chronic wounds frequently tend to contact sensitizations, and colophony currently represents the 4th most frequent allergen in Germany. Therefore, highly potent allergens such as colophony should be strictly avoided as a content material of modern wound dressings.
一名62岁患有腿部静脉溃疡的女性患者,在使用水胶体敷料Varihesive进行伤口床准备期间出现了大面积湿疹。斑贴试验证实,除了对松香过敏外,对水胶体敷料也有明显的致敏反应。在查阅当前文献后,我们发现过去10年中有几例关于对水胶体致敏的病例报告,这些水胶体敷料成分相同,但在不同国家以不同品牌名称销售。这些敷料含有氢化松香季戊四醇酯作为增粘剂,该物质保留了松香的致敏潜力。特别是患有慢性伤口的患者经常容易发生接触性致敏,松香目前是德国第四常见的过敏原。因此,应严格避免将强效过敏原如松香作为现代伤口敷料的成分材料。