Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany.
Cancer Lett. 2013 Jul 28;335(2):441-6. doi: 10.1016/j.canlet.2013.02.049. Epub 2013 Mar 6.
Human gene icb-1 has been originally identified to be involved in differentiation processes of cancer cells. To examine the function of icb-1 in ovarian cancer, we knocked down its expression in three ovarian cancer cell lines and performed microarray-based gene expression profiling with subsequent gene network modeling. Loss of icb-1 expression accelerated proliferation of SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of ovarian cancer biomarkers like KLK10 and CLDN16. Most of the upregulated genes were part of oncogenic pathways regulated by ERα or TNF. Our data suggest that icb-1 gene inhibits growth and progression of ovarian cancer cells.
人类基因 icb-1 最初被鉴定为参与癌细胞的分化过程。为了研究 icb-1 在卵巢癌中的功能，我们敲低了三种卵巢癌细胞系中的 icb-1 表达，并进行了基于微阵列的基因表达谱分析和随后的基因网络建模。icb-1 表达的缺失加速了 SK-OV-3、OVCAR-3 和 OAW-42 细胞的增殖，并导致卵巢癌生物标志物如 KLK10 和 CLDN16 的上调。大多数上调的基因是受 ERα 或 TNF 调节的致癌途径的一部分。我们的数据表明，icb-1 基因抑制卵巢癌细胞的生长和进展。
