Segarra Ana B, Prieto Isabel, Banegas Inmaculada, Villarejo Ana B, Wangensteen Rosemary, de Gasparo Marc, Vives Francisco, Ramírez-Sánchez Manuel
Unit of Physiology, University of Jaén, 23071 Jaén, Spain.
Int J Hypertens. 2013;2013:156179. doi: 10.1155/2013/156179. Epub 2013 Feb 12.
The model of neurovisceral integration suggests that the frontal cortex (FC) and the cardiovascular function are reciprocally and asymmetrically connected. We analyzed several angiotensinase activities in the heart left ventricle (VT) of control and captopril-treated SHR, and we search for a relationship between these activities and those determined in the left and right FC. Captopril was administered in drinking water for 4 weeks. Samples from the left VT and from the left and right FC were obtained. Soluble and membrane-bound enzymatic activities were measured fluorometrically using arylamides as substrates. The weight of heart significantly decreased after treatment with captopril, mainly, due to the reduction of the left VT weight. In the VT, no differences for soluble activities were observed between control and treated SHR. In contrast, a generalized significant reduction was observed for membrane-bound activities. The most significant correlations between FC and VT were observed in the right FC of the captopril-treated group. The other correlations, right FC versus VT and left FC versus VT in controls and left FC versus VT in the captopril group, were few and low. These results confirm that the connection between FC and cardiovascular system is asymmetrically organized.
神经内脏整合模型表明，额叶皮质（FC）与心血管功能之间存在相互且不对称的联系。我们分析了对照组和卡托普利治疗的自发性高血压大鼠（SHR）心脏左心室（VT）中的几种血管紧张素酶活性，并探寻这些活性与左右额叶皮质中所测定活性之间的关系。将卡托普利加入饮用水中给药4周。获取左心室以及左右额叶皮质的样本。使用芳基酰胺作为底物，通过荧光法测定可溶性和膜结合酶活性。卡托普利治疗后心脏重量显著降低，主要是由于左心室重量减轻。在心室中，对照组和治疗组的SHR之间可溶性活性未观察到差异。相反，膜结合活性普遍显著降低。在卡托普利治疗组的右侧额叶皮质中观察到额叶皮质与心室之间的相关性最为显著。其他相关性，即对照组中右侧额叶皮质与心室、左侧额叶皮质与心室以及卡托普利组中左侧额叶皮质与心室之间的相关性较少且程度较低。这些结果证实额叶皮质与心血管系统之间的联系是不对称组织的。
