一种化学酶法来特异性地点击修饰 RNA。
A chemo-enzymatic approach to specifically click-modified RNA.
机构信息
Humboldt Universität zu Berlin, Institute for Chemistry, Brook-Taylor-Str. 2, 12489 Berlin, Germany.
出版信息
Chem Commun (Camb). 2013 Apr 18;49(30):3128-30. doi: 10.1039/c3cc40594j. Epub 2013 Mar 11.
PMID:23476924
Abstract
The growing interest in single-molecule analysis of RNA calls for programmable enzymatic labeling strategies beyond the horizon of solid-phase synthesized RNAs. Herein we describe an easy and versatile chemo-enzymatic approach to label RNA at its termini or defined internal positions via click-chemistry.
摘要
对 RNA 单分子分析的兴趣日益浓厚，这就要求超越固相合成 RNA 的范畴，开发可编程的酶标记策略。在此，我们描述了一种简单而通用的化学酶法策略，通过点击化学在 RNA 的末端或定义的内部位置进行标记。
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