[波斯菊的化学成分]

[Chemical constituents of Coreopsis tinctoria].

作者信息

Zhang Yuan, Tu Peng-Fei

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2012 Dec;37(23):3581-4.

PMID:23477144

Abstract

OBJECTIVE

To study the chemical constituents of the inflorescences of Coreopsis tinctoria and provide the chemical basis for development and utilization of this plant.

METHOD

Various chromatographic techniques were employed for the isolation and purification of the constituents including silica gel, Sephadex LH-20 and pre-HPLC. The structures of compounds were elucidated by chemical and spectral analysis (NMR, IR, UV and MS).

RESULT

Eight compounds have been isolated from the inflorescences of C. tinctoria, including three organic acids which are 3,4-dihydroxybenzoicacid (1), 4-hydroxybenzoicacid (2) and caffeic acid (3), one organic ester which is 4-O-beta-D-glucopyranosyl-p-coumaric acid methyl ester (4), two flavonones which are 2S-3',5',7-trihydroxyflavanone (5) and (2R,3R)-3,4',5,7-tetrahydroxylflavanone (6), two sterols which are stigmasterol-3-O-beta-D-glucopyranoside (7) and beta-sitosterol (8).

CONCLUSION

Compounds 1-7 were isolated from genus Coreopsis for the first time and compound 8 was isolated first from C. tinctoria.

摘要

目的

研究波斯菊花序的化学成分，为该植物的开发利用提供化学依据。

方法

采用多种色谱技术，包括硅胶、葡聚糖凝胶LH - 20和制备型高效液相色谱，对其成分进行分离和纯化。通过化学和光谱分析（核磁共振、红外光谱、紫外光谱和质谱）确定化合物的结构。

结果

从波斯菊花序中分离出8种化合物，包括3种有机酸，即3,4 - 二羟基苯甲酸（1）、4 - 羟基苯甲酸（2）和咖啡酸（3）；1种有机酯，即4 - O - β - D - 吡喃葡萄糖基 - 对香豆酸甲酯（4）；2种黄酮酮，即2S - 3',5',7 - 三羟基黄烷酮（5）和（2R,3R）- 3,4',5,7 - 四羟基黄烷酮（6）；2种甾醇，即豆甾醇 - 3 - O - β - D - 吡喃葡萄糖苷（7）和β - 谷甾醇（8）。