Department of Neurosciences, University of Padova, Via Venezia 90, 35100 Padova, Italy.
Nanomedicine (Lond). 2013 Mar;8(3):469-86. doi: 10.2217/nnm.13.12.
Stem cells (SCs) are undifferentiated cells responsible for the growth, homeostasis and repair of many tissues. The maintenance and survival of SCs is strongly influenced by several stimuli from the local microenvironment. The majority of signaling molecules interact with SCs at the nanoscale level. Therefore, scaffolds with surface nanostructures have potential applications for SCs and in the field of regenerative medicine. Although some strategies have already reached the field of cell biology, strategies based on modification at nanoscale level are new players in the fields of SCs and tissue regeneration. The introduction of the possibility to perform such modifications to these fields is probably due to increasing improvements in nanomaterials for biomedical applications, as well as new insights into SC biology. The aim of the present review is to exhibit the most recent applications of nanostructured materials that drive the commitment of adult SCs for potential clinical applications.
干细胞（SCs）是未分化的细胞，负责许多组织的生长、稳态和修复。SCs 的维持和存活受到来自局部微环境的多种刺激的强烈影响。大多数信号分子在纳米级水平与SCs 相互作用。因此，具有表面纳米结构的支架在SCs 和再生医学领域具有潜在的应用。尽管一些策略已经进入细胞生物学领域，但基于纳米级修饰的策略是SCs 和组织再生领域的新参与者。将这种修饰引入这些领域的可能性可能归因于生物医学应用的纳米材料的不断改进，以及对SCs 生物学的新认识。本综述的目的是展示最新的纳米结构材料应用，这些应用推动了成体SCs 的定向分化，为潜在的临床应用提供可能。
