Baier R J, Hasan S U, Cates D B, Hooper D, Nowaczyk B, Rigatto H
Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
J Appl Physiol (1985). 1990 Apr;68(4):1597-604. doi: 10.1152/jappl.1990.68.4.1597.
To test the hypothesis that continuous fetal breathing could be induced by hyperoxemia alone or by hyperoxemia and umbilical cord occlusion, even in the absence of a rise in arterial PCO2 (PaCO2), we studied 18 chronically instrumented fetal sheep on 34 occasions using our window model (18). After a resting cycle (1 low-voltage followed by 1 high-voltage electrocortical activity epoch), the fetal lung was distended via an endotracheal tube using mean airway pressure of approximately cmH2O. Inspired N2, 17% O2, and 100% O2 were given to the fetus during one cycle each. While 100% O2 was given, the umbilical cord was occluded (balloon cuff).(ABSTRACT TRUNCATED AT 250 WORDS)
为了验证即使在动脉血二氧化碳分压（PaCO2）不升高的情况下，单纯高氧血症或高氧血症与脐带闭塞能否诱导胎儿持续呼吸的假说，我们使用窗口模型（18），在34个不同场合对18只长期植入仪器的胎羊进行了研究。在一个静息周期（1个低电压随后是1个高电压皮质电活动期）后，通过气管内导管以约厘米水柱的平均气道压力扩张胎儿肺部。在每个周期中分别向胎儿给予吸入氮气、17%氧气和100%氧气。在给予100%氧气时，脐带被闭塞（球囊袖带）。（摘要截断于250字）
