激活 p53 的代谢刹车可驱动衰老。
Engaging the p53 metabolic brake drives senescence.
机构信息
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Cell Res. 2013 Jun;23(6):739-40. doi: 10.1038/cr.2013.34. Epub 2013 Mar 12.
Abstract
Emerging evidence suggests that the ability of p53 to regulate metabolism is important for its tumor suppressor activity. A recent study published in Nature reveals a novel connection between p53 and metabolism: p53 transcriptionally represses the expression of malic enzymes and associated NADPH production, which in turn triggers a positive feedback loop resulting in sustained p53 activation, cellular senescence, and tumor suppression.
摘要
新出现的证据表明，p53 调节代谢的能力对其肿瘤抑制活性很重要。最近发表在《自然》杂志上的一项研究揭示了 p53 与代谢之间的一种新的联系：p53 转录抑制苹果酸酶的表达和相关的 NADPH 产生，这反过来又触发了一个正反馈回路，导致持续的 p53 激活、细胞衰老和肿瘤抑制。
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本文引用的文献
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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.p53 和苹果酸酶的相互调节控制代谢和衰老。
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