新型查尔酮衍生物的合成及抗肿瘤活性。
Synthesis and antitumor activity of novel chalcone derivatives.
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152, Luoyu Road, Wuhan 430079, PR China.
出版信息
Biomed Pharmacother. 2013 Apr;67(3):215-7. doi: 10.1016/j.biopha.2010.12.010. Epub 2010 Dec 30.
A novel series of chalcone derivatives containing pyrimidinyl group were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines. Most of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. The compound 5g displayed more potent cytotoxic activities against human cancer cell lines in comparison with Curcumin.
合成了一系列新型的含嘧啶基查尔酮衍生物，并评估了它们对各种人癌细胞系的体外细胞毒性活性。大多数制备的化合物对几种人癌细胞系表现出潜在的细胞毒性。与姜黄素相比，化合物 5g 对人癌细胞系表现出更强的细胞毒性活性。
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