Clary C, Mandos L A, Schweizer E
Department of Psychiatry, University of Pennsylvania, Philadelphia.
J Clin Psychiatry. 1990 Jun;51(6):226-31.
Four hundred eighty-five psychiatrists in Pennsylvania and Delaware responded to a survey of prescribing practices for the monoamine oxidase inhibitor (MAOI) antidepressants. Although the low response rate (34%) limited the generalizability of the results, the similarity between respondents and the total sample surveyed argued against gross sampling bias. The authors found that only a minority of psychiatrists (25%) prescribe MAOIs regularly, despite a relatively low rate of reports of serious sequelae from hypertensive crises or other side effects. They also found that a substantial number of psychiatrists who regularly prescribe MAOIs also report prescribing high doses and combining therapy with tricyclics, lithium, neuroleptics, and psychostimulants. These findings have implications for postmarketing research on psychotropic drugs.
宾夕法尼亚州和特拉华州的485名精神科医生回复了一项关于单胺氧化酶抑制剂（MAOI）类抗抑郁药处方习惯的调查。尽管低回复率（34%）限制了结果的普遍性，但回复者与被调查的总样本之间的相似性表明不存在严重的抽样偏差。作者发现，尽管高血压危象或其他副作用的严重后遗症报告率相对较低，但只有少数精神科医生（25%）经常开具MAOI类药物。他们还发现，大量经常开具MAOI类药物的精神科医生还报告开具高剂量药物，并将MAOI类药物与三环类药物、锂盐、抗精神病药物和精神兴奋剂联合使用。这些发现对精神药物的上市后研究具有启示意义。
