• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.

作者信息

Mupo A, Celani L, Dovey O, Cooper J L, Grove C, Rad R, Sportoletti P, Falini B, Bradley A, Vassiliou G S

出版信息

Leukemia. 2013 Sep;27(9):1917-20. doi: 10.1038/leu.2013.77. Epub 2013 Mar 12.

DOI:10.1038/leu.2013.77
PMID:23478666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3768110/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6f/3768110/2d006b77d6c0/leu201377f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6f/3768110/cdab6a12e865/leu201377f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6f/3768110/2d006b77d6c0/leu201377f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6f/3768110/cdab6a12e865/leu201377f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6f/3768110/2d006b77d6c0/leu201377f2.jpg

相似文献

1
A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.突变型核仁磷酸蛋白与Flt3内部串联重复序列之间强大的分子协同作用在小鼠中引发急性髓系白血病。
Leukemia. 2013 Sep;27(9):1917-20. doi: 10.1038/leu.2013.77. Epub 2013 Mar 12.
2
"Cup-like" blasts and NPM1 and FLT3 (ITD) mutations in acute myeloid leukemia (AML).急性髓系白血病（AML）中的“杯状”原始细胞以及NPM1和FLT3（内部串联重复，ITD）突变
Int J Hematol. 2013 Jul;98(1):3. doi: 10.1007/s12185-013-1371-3. Epub 2013 May 21.
3
NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia.NPM1c 改变急性髓系白血病中 FLT3-D835Y 的定位和信号转导。
Blood. 2019 Jul 25;134(4):383-388. doi: 10.1182/blood.2018883140. Epub 2019 Jun 11.
4
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.在一大群年轻成年急性髓系白血病患者中，FLT3内部串联重复突变水平、数量、大小以及与NPM1突变相互作用的影响。
Blood. 2008 Mar 1;111(5):2776-84. doi: 10.1182/blood-2007-08-109090. Epub 2007 Oct 23.
5
Association of cup-like nuclei in blasts with FLT3 and NPM1 mutations in acute myeloid leukemia.急性髓系白血病中伴有 FLT3 和 NPM1 突变的原始细胞中杯状核的相关性。
Ann Hematol. 2013 Apr;92(4):451-7. doi: 10.1007/s00277-012-1645-5. Epub 2012 Dec 13.
6
Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells.异常定位的致癌酪氨酸激酶导致 Ras 激活的特点：FLT3 ITD 在急性髓系白血病细胞的质膜上通过 K-Ras 信号传导。
J Cell Sci. 2013 Oct 15;126(Pt 20):4746-55. doi: 10.1242/jcs.131789. Epub 2013 Aug 13.
7
[Correlation of Fms-like tyrosine kinase 3 (FLT3) gene expression to FLT3/internal tandem duplication mutation in peripheral blood of acute myeloid leukemia.].急性髓系白血病患者外周血中Fms样酪氨酸激酶3（FLT3）基因表达与FLT3内部串联重复突变的相关性
Ai Zheng. 2009 Jun;28(6):632-6.
8
A model for prediction of FLT3-ITD and NPM1 (without FLT3-ITD) positivity in patients with newly diagnosed acute myeloid leukaemia.一种用于预测新诊断急性髓系白血病患者FLT3-ITD阳性和NPM1（无FLT3-ITD）阳性的模型。
Br J Haematol. 2013 Oct;163(1):130-2. doi: 10.1111/bjh.12450. Epub 2013 Jul 6.
9
Prognostic implications of NPM1 mutations and FLT3 internal tandem duplications in Egyptian patients with cytogenetically normal acute myeloid leukemia.NPM1突变和FLT3内部串联重复在埃及细胞遗传学正常的急性髓系白血病患者中的预后意义
Hematology. 2014 Jan;19(1):22-30. doi: 10.1179/1607845413Y.0000000085. Epub 2013 Nov 25.
10
Correlation between peripheral blood and bone marrow regarding FLT3-ITD and NPM1 mutational status in patients with acute myeloid leukemia.急性髓系白血病患者外周血与骨髓中FLT3-ITD和NPM1突变状态的相关性
Haematologica. 2015 Mar;100(3):e97-8. doi: 10.3324/haematol.2014.118422. Epub 2014 Dec 19.

引用本文的文献

1
Mutant cooperates with or to drive distinct myeloid diseases and molecular outcomes.突变体协同或驱动不同的髓系疾病及分子结果。
Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2415779122. doi: 10.1073/pnas.2415779122. Epub 2025 May 16.
2
Targeting leukemic stem cell dormancy in --driven acute myeloid leukemia.靶向在--驱动的急性髓系白血病中的白血病干细胞休眠
Haematologica. 2025 Sep 1;110(9):1900-1902. doi: 10.3324/haematol.2025.287644. Epub 2025 May 8.
3
Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis.

本文引用的文献

1
The origin and evolution of mutations in acute myeloid leukemia.急性髓细胞白血病突变的起源和演变。
Cell. 2012 Jul 20;150(2):264-78. doi: 10.1016/j.cell.2012.06.023.
2
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.IDH1(R132H) 突变增加了小鼠造血祖细胞并改变了表观遗传学。
Nature. 2012 Aug 30;488(7413):656-9. doi: 10.1038/nature11323.
3
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.急性髓系白血病中综合基因分析的预后相关性。
核磷蛋白突变导致的干细胞休眠是髓系白血病发生过程中不受限制的自我更新的关键决定因素。
Haematologica. 2025 Mar 13. doi: 10.3324/haematol.2024.286577.
4
Functions of the native NPM1 protein and its leukemic mutant.天然NPM1蛋白及其白血病突变体的功能。
Leukemia. 2025 Feb;39(2):276-290. doi: 10.1038/s41375-024-02476-4. Epub 2024 Dec 17.
5
Perspectives and challenges of small molecule inhibitor therapy for FLT3-mutated acute myeloid leukemia.FLT3 突变型急性髓系白血病小分子抑制剂治疗的观点与挑战。
Ann Hematol. 2024 Jul;103(7):2215-2229. doi: 10.1007/s00277-023-05545-3. Epub 2023 Nov 17.
6
In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis.体内筛选鉴定正常和恶性造血过程中染色质因子的功能。
Nat Genet. 2023 Sep;55(9):1542-1554. doi: 10.1038/s41588-023-01471-2. Epub 2023 Aug 14.
7
Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1.携带突变型 NPM1 的 AML 细胞对新型治疗药物疗效的因果关联。
Leukemia. 2023 Jun;37(6):1336-1348. doi: 10.1038/s41375-023-01882-4. Epub 2023 Mar 28.
8
Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.Cre 重组酶表达与纯合性 FLT3 内部串联重复 knockin 小鼠模型协同诱导急性髓系白血病。
Leukemia. 2023 Apr;37(4):741-750. doi: 10.1038/s41375-023-01832-0. Epub 2023 Feb 4.
9
Modelling acute myeloid leukemia (AML): What's new? A transition from the classical to the modern.建模急性髓系白血病 (AML)：有何新进展？从经典到现代的转变。
Drug Deliv Transl Res. 2023 Aug;13(8):2110-2141. doi: 10.1007/s13346-022-01189-4. Epub 2022 Aug 5.
10
Murine Models of Acute Myeloid Leukemia.急性髓系白血病的小鼠模型
Front Oncol. 2022 Jun 8;12:854973. doi: 10.3389/fonc.2022.854973. eCollection 2022.
N Engl J Med. 2012 Mar 22;366(12):1079-89. doi: 10.1056/NEJMoa1112304. Epub 2012 Mar 14.
4
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.FLT3/ITD 突变的基因敲入与 NUP98-HOXD13 融合协同作用在小鼠模型中产生急性髓系白血病。
Blood. 2012 Mar 22;119(12):2883-94. doi: 10.1182/blood-2011-10-382283. Epub 2012 Feb 8.
5
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.突变核仁磷酸蛋白和协同途径驱动小鼠白血病的起始和进展。
Nat Genet. 2011 May;43(5):470-5. doi: 10.1038/ng.796. Epub 2011 Mar 27.
6
Independent prognostic factors for AML outcome.AML 预后的独立预后因素。
Hematology Am Soc Hematol Educ Program. 2009:385-95. doi: 10.1182/asheducation-2009.1.385.
7
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.NPM1突变的急性髓系白血病中核磷蛋白转运改变：分子基础及临床意义
Leukemia. 2009 Oct;23(10):1731-43. doi: 10.1038/leu.2009.124. Epub 2009 Jun 11.
8
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.在慢性粒单核细胞白血病小鼠模型中，FLT3突变赋予多能祖细胞增强的增殖和存活特性。
Cancer Cell. 2007 Oct;12(4):367-80. doi: 10.1016/j.ccr.2007.08.031.
9
The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.Flt3受体酪氨酸激酶在急性髓系白血病中与NUP98-HOX融合蛋白协同作用。
Blood. 2006 Aug 1;108(3):1030-6. doi: 10.1182/blood-2005-12-007005.
10
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.核仁磷酸蛋白在核型正常的急性髓系白血病中的表达
N Engl J Med. 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974.