Jiménez-Salas Z, Hernández-Tobías E A, Ramírez-López T E, Campos-Góngora E
Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
Nutr Hosp. 2012 Sep-Oct;27(5):1505-10. doi: 10.3305/nh.2012.27.5.5673.
Osteoporosis is a multifactorial disease characterized by a low bone mineral density (BMD). Osteoporosis and the occurrence of fractures in postmenopausal women have been associated to the TaqI polymorphism in the vitamin D receptor (VDR) gene.
To analyze the association of the different genotypes of TaqI polymorphism of the VDR gene with BMD in young Mexican women.
Dual X-ray absorptiometry was carried out in 150 women aged 19 to 29 years in order to determine their total bone mineral density (tBMD) and dual BMD of the femur (dfBMD). DNA was extracted from peripheral blood to determine the genotype of the TaqI polymorphism in the VDR gene. The data obtained were analyzed by simple linear regression and ANOVA.
Mean tBMD was 1.096 ± 0.064 mean dfBMD was 0.960 ± 0.107 g/cm². The frequency of the TaqI polymorphisms was 57% (TT), 37% (Tt) and 6% (tt), the frequency of the alleles was 75% (T) and 25% (t). Ths statistical analysis showed a lack of association between BMD and the genotypes of TaqI polymorphism in the VDR gene.
These results suggest that may exist factors other than the TaqI polymorphism in the VDR gene contributing to BMD in young women from Northern Mexico.
骨质疏松症是一种以低骨矿物质密度（BMD）为特征的多因素疾病。绝经后女性的骨质疏松症及骨折发生与维生素D受体（VDR）基因中的TaqI多态性有关。
分析VDR基因TaqI多态性的不同基因型与墨西哥年轻女性骨密度的关联。
对150名年龄在19至29岁的女性进行双能X线吸收测定，以确定她们的总骨矿物质密度（tBMD）和股骨双能骨密度（dfBMD）。从外周血中提取DNA，以确定VDR基因中TaqI多态性的基因型。对获得的数据进行简单线性回归和方差分析。
平均tBMD为1.096±0.064，平均dfBMD为0.960±0.107g/cm²。TaqI多态性的频率为57%（TT）、37%（Tt）和6%（tt），等位基因频率为75%（T）和25%（t）。统计分析表明，骨密度与VDR基因中TaqI多态性的基因型之间缺乏关联。
这些结果表明，在墨西哥北部的年轻女性中，可能存在VDR基因TaqI多态性以外的其他因素影响骨密度。
