Hyakuna K, Yamamuro T, Kotoura Y, Oka M, Nakamura T, Kitsugi T, Kokubo T, Kushitani H
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
J Biomed Mater Res. 1990 Apr;24(4):471-88. doi: 10.1002/jbm.820240406.
The surface reactions of calcium phosphate ceramics have been thought to play an important role in bonding with living bone. Hydroxyapatite (HA), tricalcium phosphate (TCP), and two kinds of apatite-containing glass ceramics were immersed in three types of solutions with different chemical constituents. The first solution was a physiological saline, the second contained phosphate (PO4), and the third was a balanced salt solution consisting of calcium (Ca), magnesium (Mg), and PO4. After serial incubation periods, changes in the solutions were assessed by measurement of total Ca, Mg, and PO4. The ceramic surfaces were studied using scanning electron spectroscopy, infrared reflection spectroscopy, and thin-film x-ray diffraction. The surface reactions of the ceramics were greatly affected by the chemical compositions of the surrounding media. In the complete solution with both Ca and PO4, a carbonated apatite layer was formed on the surfaces of HA, TCP, and the glass ceramics. In comparison to HA and TCP, the glass ceramics were characterized as Ca-releasing materials, the dissolved Ca creating an apatite layer on the surfaces in a few days, in conjunction with PO4 stock in the surrounding media. The immersion test with various solutions proved to be a simple and effective method of assessing surface conditions of ceramic materials.
磷酸钙陶瓷的表面反应被认为在与活骨结合中起重要作用。将羟基磷灰石（HA）、磷酸三钙（TCP）和两种含磷灰石的玻璃陶瓷浸泡在三种化学成分不同的溶液中。第一种溶液是生理盐水，第二种含有磷酸盐（PO4），第三种是由钙（Ca）、镁（Mg）和PO4组成的平衡盐溶液。在连续的孵育期后，通过测量总Ca、Mg和PO4来评估溶液的变化。使用扫描电子光谱、红外反射光谱和薄膜X射线衍射研究陶瓷表面。陶瓷的表面反应受到周围介质化学成分的极大影响。在含有Ca和PO4的完全溶液中，HA、TCP和玻璃陶瓷表面形成了碳酸化磷灰石层。与HA和TCP相比，玻璃陶瓷的特点是可释放Ca的材料，溶解的Ca在几天内与周围介质中的PO4储备一起在表面形成磷灰石层。用各种溶液进行的浸泡试验被证明是评估陶瓷材料表面状况的一种简单有效的方法。
