Yang H Y, Thompson I, Yang S F, Chi X P, Evans J R G, Cook R J
Department of Materials, Queen Mary, University of London, London, E1 4NS, UK.
J Mater Sci Mater Med. 2008 Nov;19(11):3345-53. doi: 10.1007/s10856-008-3473-7. Epub 2008 Jun 11.
The dissolution behaviour of calcium phosphate filaments made by extrusion freeforming for hard tissue scaffolds was measured. The solubility of filaments with different HA/beta-TCP ratios sintered at temperatures from 1,100 to 1,300 degrees C was measured under simulated physiological conditions (tris buffer solution: tris(hydroxyl) methyl-aminomethane-HCl), pH 7.4, 37 degrees C). Calcium and phosphate concentrations were measured separately by inductively coupled plasma (ICP) atomic emission spectroscopy. Surface morphologies and composition before and after immersion were analyzed by SEM and EDS. The results clearly show that as the beta-TCP content increased, the dissolution increased. Higher sintering temperatures, with consequent closure of surface pores, resulted in lower dissolution. Examination of the surface suggested dissolution on preferred sites by pitting.
对通过挤压自由成型法制造的用于硬组织支架的磷酸钙长丝的溶解行为进行了测量。在模拟生理条件（三羟甲基氨基甲烷 - 盐酸缓冲溶液）、pH值7.4、37℃下，测量了在1100至1300℃温度下烧结的不同HA/β - TCP比例长丝的溶解度。通过电感耦合等离子体（ICP）原子发射光谱法分别测量钙和磷的浓度。通过扫描电子显微镜（SEM）和能谱仪（EDS）分析浸泡前后的表面形态和成分。结果清楚地表明，随着β - TCP含量的增加，溶解度增加。较高的烧结温度导致表面孔隙封闭，从而使溶解度降低。对表面的检查表明，溶解发生在优先位点上，表现为点蚀。
