[阿托烷类：它们的抗溃疡作用及其可能机制]
[Atranes: their ulcerostatic effect and its possible mechanisms].
作者信息
Kuznetsov I G, Rasulov M M, Voronkov M G
出版信息
Izv Akad Nauk SSSR Biol. 1990 Jan-Feb(1):67-74.
The ulcerostatic activity of methylethyl (sylathrane-1-ilmethyl) sulfoiodide, 1-(chlormethyl) sylatrane, and 1-(isopropoxy)hermatrane has been revealed at experimental acetate ulcer in rats. The effect of atranes was equal to that of oxyferriscorbone and exceeded that of methyluracil. All the compounds studied inhibited peroxide oxidation of lipids in blood and stomach tissues from ulcer and in model experiments in egg yolk liposomes. The processes of ulcer development and photodynamic effects of lipid peroxidation in biological objects have been summarized. The data obtained allow to conclude that the ulcerostatic mechanism of action effect of atranes and the comparable drugs is based on their antioxidative effect.
甲乙基（1-硅氮杂环丁烷基亚甲基）硫代碘化物、1-（氯甲基）硅氮杂环丁烷和1-（异丙氧基）降冰片烷在大鼠实验性醋酸溃疡模型中显示出抗溃疡活性。氮杂环丁烷类化合物的效果与氧化抗坏血酸相当，且优于甲基尿嘧啶。所有研究的化合物均抑制溃疡大鼠血液和胃组织以及蛋黄脂质体模型实验中脂质的过氧化反应。总结了生物物体中溃疡发展过程和脂质过氧化的光动力效应。所得数据表明，氮杂环丁烷类化合物及类似药物的抗溃疡作用机制基于其抗氧化作用。
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