Biomedical Sciences Department, Defence Science and Technology Laboratory, Salisbury, Wilts, UK.
Clin Exp Immunol. 2013 Apr;172(1):1-8. doi: 10.1111/cei.12044.
The causative organism of plague is the bacterium Yersinia pestis. Advances in understanding the complex pathogenesis of plague infection have led to the identification of the F1- and V-antigens as key components of a next-generation vaccine for plague, which have the potential to be effective against all forms of the disease. Here we review the roles of F1- and V-antigens in the context of the range of virulence mechanisms deployed by Y. pestis, in order to develop a greater understanding of the protective immune responses required to protect against plague.
鼠疫的病原体是鼠疫耶尔森菌。对鼠疫感染复杂发病机制的认识的进步，导致了 F1-和 V-抗原被鉴定为鼠疫新一代疫苗的关键成分，这种疫苗有可能对所有形式的疾病都有效。在这里，我们根据鼠疫耶尔森菌所采用的一系列毒力机制来综述 F1-和 V-抗原的作用，以便更好地了解预防鼠疫所需的保护性免疫反应。
