Cooper C, Wickham C, Lacey R F, Barker D J
MRC Environmental Epidemiology Unit, Southampton General Hospital, United Kingdom.
J Epidemiol Community Health. 1990 Mar;44(1):17-9. doi: 10.1136/jech.44.1.17.
The aim of the study was to examine the relationship between water fluoride concentration and the incidence of hip fracture, since evidence on this is at present inconsistent.
Numbers of hospital admissions for fractures of proximal femur were obtained from hospital activity analysis data for the years 1978-1982. The fracture rates were compared with water fluoride concentrations in 39 county districts of England and Wales (fluoride concentrations had been measured in these districts between 1969 and 1973 as part of the British Regional Heart Study).
During the study period, 4121 men and 16,272 women aged 45 years and over were discharged from hospital after hip fracture.
Poor correlations were found between discharge rates and both total (r = 0.16, p = 0.34) and natural (r = 0.01, p = 0.95) water fluoride concentrations.
Water fluoridation to levels of around 1 mg/litre is unlikely to reduce hip fracture incidence markedly in this country.
本研究旨在探讨水氟浓度与髋部骨折发生率之间的关系，因为目前关于这方面的证据并不一致。
从1978 - 1982年医院活动分析数据中获取股骨近端骨折的住院人数。将骨折发生率与英格兰和威尔士39个县区的水氟浓度进行比较（作为英国地区心脏研究的一部分，这些地区在1969年至1973年间测量了氟浓度）。
在研究期间，4121名男性和16272名45岁及以上的女性在髋部骨折后出院。
出院率与总水氟浓度（r = 0.16，p = 0.34）和天然水氟浓度（r = 0.01，p = 0.95）之间的相关性均较差。
在该国，将水氟含量提高到约1毫克/升不太可能显著降低髋部骨折的发生率。
