Jorgensen A, Parnas J
Psykologisk Institut, University Department of Psychiatry, Cophenhagen, Denmark.
J Nerv Ment Dis. 1990 Jun;178(6):370-6. doi: 10.1097/00005053-199006000-00005.
In a sample of 129 female schizophrenic patients followed for a period of 22 years, an analysis of intercorrelations between background, premorbid, and clinical variables was performed. Poor outcome, as measured by amount of hospitalization, was associated with premorbid psychopathic traits, defective premorbid social adjustment, early onset, and nonparanoid subtype of schizophrenia. Formal thought disorder, positive symptoms, and negative symptoms were positively intercorrelated. Schneiderian first-rank symptoms were predictors of better outcome and they were preceded by premorbid obsessive traits and lack of premorbid psychopathic and histrionic traits. These latter traits were predictive of early onset, nonparanoid schizophrenia. It is postulated that personality dimensions can exert a pathoplastic influence through their capacity to promote adaptive mechanisms. Negative symptoms seem to represent a conglomerate of various phenomena, some of which were preceded by premorbid schizoid traits.
在对129名女性精神分裂症患者进行了为期22年的随访样本中，对背景、病前和临床变量之间的相互关系进行了分析。以住院次数衡量的不良预后与病前精神病性特质、病前社会适应不良、发病早以及精神分裂症的非偏执型亚型有关。形式思维障碍、阳性症状和阴性症状呈正相关。施奈德一级症状是预后较好的预测指标，且病前有强迫性特质以及缺乏病前精神病性和表演性特质先于这些症状出现。后述这些特质可预测发病早、非偏执型精神分裂症。据推测，人格维度可通过其促进适应机制的能力发挥病理塑形影响。阴性症状似乎代表了各种现象的集合，其中一些现象之前有病前分裂样特质。
