通过二氧化碳滴定曲线评估人体酸碱平衡紊乱

The assessment of acid-base disturbance in man by the use of carbon dioxide titration curves.

Stoker J B, Kappagoda C T, Snow H M, Linden R J

Clin Sci Mol Med. 1975 Feb;48(2):133-8. doi: 10.1042/cs0480133.

Abstract

Carbon dioxide titration curves were determined in vivo in dog and man at various degrees of acute non-respiratory acidaemia and alkalaemia. 2. The slope of the CO2 titration curve (delta log Pco2/delta pH) was found to increase with the severity of the acute non-respiratory alkalaemia the slope (delta log Pco2/delta pH) tended towards unity. 3. A simple scheme based on the CO2 titration curves determined in vivo has been proposed for the assessment of acute acid-base disturbances in man. 4. Carbon dioxide titration curves were also determined in vivo in patients with chronic respiratory and non-respiratory acidaemia and it was found that these curves were not significantly different from those obtained in states of acute acid-base disturbances. It is therefore suggested that the scheme described in this paper is applicable to all acid-base disturbances.

摘要

在狗和人体中，于不同程度的急性非呼吸性酸血症和碱血症状态下测定了二氧化碳滴定曲线。2. 发现二氧化碳滴定曲线的斜率（δlog Pco₂/δpH）随着急性非呼吸性碱血症的严重程度增加而增大，该斜率（δlog Pco₂/δpH）趋于1。3. 已提出一种基于体内测定的二氧化碳滴定曲线的简单方案，用于评估人体急性酸碱紊乱。4. 还在患有慢性呼吸性和非呼吸性酸血症的患者体内测定了二氧化碳滴定曲线，发现这些曲线与在急性酸碱紊乱状态下获得的曲线无显著差异。因此建议本文所述方案适用于所有酸碱紊乱。