Crew M C, Mitchell L, de la Iglesia F, Di Carlo F J
Drug Metab Dispos. 1975 Jan-Feb;3(1):10-4.
Oxisuran metabolism was studied in the Rhesus monkey in order to assess the suitability of this species as an immunological model for man. The biotransformation pathways observed in the monkey are the same as those seen in rats and dogs. These pathways include the oxidation of oxisuran to a sulfone not found in human plasma or urine. Nevertheless, the monkey may merit immunological evaluation because the half-lives of biotransformation and elimination, although shorter than those exhibited by man, are greater than those in dogs and rats.
为了评估恒河猴作为人类免疫学模型的适用性，对其进行了奥昔舒仑代谢研究。在恒河猴中观察到的生物转化途径与在大鼠和狗中观察到的相同。这些途径包括将奥昔舒仑氧化为一种在人血浆或尿液中未发现的砜。然而，恒河猴可能值得进行免疫学评估，因为其生物转化和消除的半衰期虽然比人类的短，但比狗和大鼠的长。
