一种新的氧杂环丁烷代谢物。
A new oxisuran metabolite.
作者信息
Leinweber F J, Greenough R C, Di Carlo F J
出版信息
Xenobiotica. 1976 Oct;6(10):617-24. doi: 10.3109/00498257609151675.
PMID:989983
Abstract
- An unidentified oxisuran metabolite which had been observed in animal urine was biosynthesized by incubating [14C]oxisuran with rat liver cytosol. 2. The metabolite, isolated by preparative t.l.c. and extraction, was identified as oxisuran alcohol sulphide by mass fragmentography. Confirmation of this identification was obtained by biosynthesis of the same compound from oxisuran sulphide. 3. The 9000 g supernatant liquid from rat liver was less effective than cytosol in reducing oxisuran to its alcohol sulphide. Neither rat liver fraction reduced oxisuran alcohol sulphoxides to sulphide. 4. The 9000 g fraction oxidized oxisuran and oxisuran alcohol sulphoxide to oxisuran alcohol sulphone.
摘要
- 通过将[14C]奥昔舒仑与大鼠肝细胞溶胶一起孵育，在动物尿液中观察到的一种未鉴定的奥昔舒仑代谢物被生物合成。2. 通过制备薄层层析和萃取分离得到的代谢物，经质量碎片分析法鉴定为奥昔舒仑醇硫化物。通过从奥昔舒仑硫化物生物合成相同化合物，对该鉴定进行了确认。3. 大鼠肝脏的9000g上清液在将奥昔舒仑还原为其醇硫化物方面比细胞溶胶效果差。大鼠肝脏的任何一个组分都不能将奥昔舒仑醇亚砜还原为硫化物。4. 9000g组分将奥昔舒仑和奥昔舒仑醇亚砜氧化为奥昔舒仑醇砜。
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