口腔鳞状细胞癌合并第二原发肿瘤患者的生存分析。
Survival analysis of patients with oral squamous cell carcinoma with simultaneous second primary tumors.
机构信息
Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
出版信息
Head Neck. 2013 Dec;35(12):1801-7. doi: 10.1002/hed.23242. Epub 2013 Mar 9.
BACKGROUND
The purpose of this study was to investigate the rate of simultaneous second primary tumor (SPT) in patients with oral squamous cell carcinoma. The survival of patients with simultaneous SPT was also compared with patients without.
METHODS
The presence of SPT was documented along with the patients' demographic data, tumor-related features, and survival status. Kaplan-Meier method was used for survival analysis. Relevant factors influencing the survival were examined by the Cox proportional hazard model.
RESULTS
A total of 897 patients' medical records were obtained. Among them, 43 patients (4.8%) had simultaneous SPT and their prognosis was poorer than that of patients without. The Cox proportional hazard model revealed that patients with simultaneous SPT tended to have a higher probability of death (relative risk [RR], 1.694; p = .015).
CONCLUSIONS
Simultaneous SPT is an independent prognostic factor for patients with oral squamous cell carcinoma. Those with simultaneous SPT have poorer survival when compared to those without.
背景
本研究旨在调查口腔鳞状细胞癌患者同时发生第二原发肿瘤（SPT）的比率。同时比较了有 SPT 和无 SPT 的患者的生存率。
方法
记录 SPT 的存在情况以及患者的人口统计学数据、肿瘤相关特征和生存状况。采用 Kaplan-Meier 法进行生存分析。采用Cox 比例风险模型检查影响生存的相关因素。
结果
共获得 897 例患者的病历。其中，43 例（4.8%）患者同时发生 SPT，其预后较无 SPT 者差。Cox 比例风险模型显示，同时发生 SPT 的患者死亡的可能性更高（相对风险[RR]，1.694；p =.015）。
结论
同时发生 SPT 是口腔鳞状细胞癌患者的独立预后因素。与无 SPT 者相比，同时发生 SPT 的患者生存率较差。
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