Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan.
Biomed Res Int. 2013;2013:125658. doi: 10.1155/2013/125658. Epub 2012 Dec 27.
Studies on two-photon absorption (2PA) photodynamic therapy (PDT) by using three water-soluble porphyrin self-assemblies consisting of ethynylene-linked conjugated bis (imidazolylporphyrin) are reviewed. 2PA cross-section values in water were obtained by an open aperture Z-scan measurement, and values were extremely large compared with those of monomeric porphyrins such as hematoporphyrin. These compounds were found to generate singlet oxygen efficiently upon one- as well as two-photon absorption as demonstrated by the time-resolved luminescence measurement at the characteristic band of singlet oxygen at 1270 nm and by using its scavenger. Photocytotoxicities for HeLa cancer cells were examined and found to be as high as those of hematoporphyrin, demonstrating that these compounds are potential candidates for 2PA-photodynamic therapy agents.
研究了由三个由乙炔键连接的共轭双咪唑基卟啉组成的水溶性卟啉自组装体的双光子吸收（2PA）光动力疗法（PDT）。通过开孔径 Z 扫描测量获得了水中的 2PA 截面值，与血卟啉等单体卟啉相比，这些值非常大。正如在 1270nm 处的单线态氧特征带的时间分辨发光测量以及使用其清除剂所证明的那样，这些化合物在单光子和双光子吸收时都能有效地产生单线态氧。检查了对 HeLa 癌细胞的光细胞毒性，发现与血卟啉一样高，表明这些化合物是双光子光动力治疗剂的潜在候选物。
