LSAMM, Institut de Chimie de Strasbourg, CNRS/UMR 7177, 4 rue Blaise Pascal, 67000 Strasbourg (France).
Angew Chem Int Ed Engl. 2015 Jan 2;54(1):169-73. doi: 10.1002/anie.201407537. Epub 2014 Nov 4.
Two-photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two-photon absorption and singlet-oxygen generation. Reported here are two new diketopyrrolopyrrole-porphyrin conjugates as robust two-photon absorbing dyes with high two-photon absorption cross-sections within the therapeutic window. Furthermore, for the first time the singlet-oxygen generation efficiency of diketopyrrolopyrrole-containing systems is investigated. A preliminary study on cell culture showed efficient two-photon induced phototoxicity.
双光子光动力疗法是一种很有前途的治疗方法，需要开发具有高效双光子吸收和单线态氧生成的敏化剂。本文报道了两种新型二酮吡咯并吡咯-卟啉缀合物，它们是具有治疗窗口内高光敏双光子吸收截面的坚固的双光子吸收染料。此外，首次研究了含二酮吡咯并吡咯的体系的单线态氧生成效率。细胞培养的初步研究表明，双光子诱导的光毒性效率很高。
