嗜铬粒蛋白在伊朗肥胖及高血压易感大鼠肾上腺中的定位。

Chromogranin location in the adrenal glands of ISIAH rats.

作者信息

Buzueva I I, Filyushina E E, Shmerling M D, Markel A L, Yakobson G S

机构信息

Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2013 Jan;154(3):393-5. doi: 10.1007/s10517-013-1958-y.

DOI:10.1007/s10517-013-1958-y

PMID:23484208

Abstract

Comparative immunohistochemical and electron microscopic study of the adrenals from hypertensive ISIAH rats and normotensive WAG rats (control) showed a more intense reaction to chromogranin A in the ISIAH adrenal in comparison with the control. Electron microscopy and morphometric analysis showed high volume and numerical densities of the secretory granules in chromaffin cells of hypertensive rats. The results indicate stimulation of the adrenal medullary substance in ISIAH rats. Presumably, intensive accumulation of chromogranin A and secretory granules in chromaffin cells of hypertensive rats reflects a certain imbalance of chromogranin A and catecholamines biogenesis, this, in turn, leading to stable stimulation of the sympathoadrenal component and higher stress sensitivity of these animals.

摘要

对高血压ISIAH大鼠和正常血压WAG大鼠（对照）肾上腺进行的免疫组织化学和电子显微镜对比研究显示，与对照组相比，ISIAH大鼠肾上腺对嗜铬粒蛋白A的反应更强。电子显微镜检查和形态计量分析表明，高血压大鼠嗜铬细胞中分泌颗粒的体积和数量密度较高。结果表明ISIAH大鼠肾上腺髓质物质受到刺激。据推测，高血压大鼠嗜铬细胞中嗜铬粒蛋白A和分泌颗粒的大量积累反映了嗜铬粒蛋白A和儿茶酚胺生物合成的某种失衡，这反过来又导致这些动物的交感肾上腺成分受到持续刺激以及更高的应激敏感性。