Wang Xiao-Qing, Zhu Xiao-Jian, Zou Ping
Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Feb;21(1):227-30. doi: 10.7534/j.issn.1009-2137.2013.01.046.
Mesenchymal stem cell-derived microvesicle (MSC-MV) is a membrane secretory system which includes microparticle and exosome, and MSC-MV is released by MSC in resting or activated state. MSC-MV selectively package the biological active substances such as lipids, proteins, mRNA and miRNA but not loads them randomly. It has definitive effect of reducing tissue injury, promoting morphological and functional recovery of the injured tissue, and this effect is probably mediated by miRNA. What is more, the MSC-MV may also possess the biological function of immunological regulation, modulation of cell growth and differentiation. The generation, constitution, and function of MSC-MV are reviewed in this article.
间充质干细胞衍生的微泡（MSC-MV）是一种膜分泌系统，包括微颗粒和外泌体，MSC-MV由处于静息或激活状态的间充质干细胞释放。MSC-MV选择性地包裹脂质、蛋白质、mRNA和miRNA等生物活性物质，而不是随机装载它们。它具有明确的减轻组织损伤、促进损伤组织形态和功能恢复的作用，这种作用可能由miRNA介导。此外，MSC-MV还可能具有免疫调节、调节细胞生长和分化的生物学功能。本文综述了MSC-MV的产生、组成和功能。
