Chen Z, Yang A D, Fei H A, Gong W L
Institute of Hematology, Xiehe Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1990;10(1):31-6. doi: 10.1007/BF02909119.
During 1987-1988 cytogenetic studies were performed in 30 patients with acute lymphoblastic leukemia (ALL). Of the 30 patients 15 (10 children and 5 adults) were found to have abnormal karyotypes including 8 cases (27%) of pseudodiploidy, 2 cases (7%) of hypodiploidy, one case (3%) of low-hyperdiploidy (modal number 47-50), and 4 cases (13%) of high-hyperdiploidy (modal number greater than 50). Immunological classification was performed by using monoclonal antibodies in 26 patients, and the most common immunophenotype was C-ALL. The patients with abnormal karyotypes were more likely to be NuLL-ALL (6 in 14) as compared with patients with normal karyotype (1 in 12). In our series, there was no significant difference between the patients with and without cytogenetic changes in regard of clinical findings such as FAB classification, the rate of complete remission, percentage of lymphoblasts in bone marrow cells and blood picture.
1987年至1988年期间，对30例急性淋巴细胞白血病（ALL）患者进行了细胞遗传学研究。在这30例患者中，有15例（10名儿童和5名成人）被发现具有异常核型，包括8例（27%）假二倍体、2例（7%）亚二倍体、1例（3%）低超二倍体（众数为47 - 50）和4例（13%）高超二倍体（众数大于50）。对26例患者使用单克隆抗体进行了免疫分类，最常见的免疫表型是普通型ALL（C-ALL）。与核型正常的患者（12例中有1例）相比，核型异常的患者更可能是无标记型ALL（NuLL-ALL，14例中有6例）。在我们的研究系列中，就FAB分类、完全缓解率、骨髓细胞和血象中原始淋巴细胞百分比等临床发现而言，有细胞遗传学改变和无细胞遗传学改变的患者之间没有显著差异。
