Hossfeld D K
Cancer Genet Cytogenet. 1987 May;26(1):59-64. doi: 10.1016/0165-4608(87)90133-6.
Results of chromosome analysis in acute lymphocytic leukemia are reviewed. Emphasis is placed on so-called specific translocations and their association with cytology, immunology, and prognosis. Data presently available suggest that chromosomes in acute lymphocytic leukemia are not only an important, independent prognostic factor, but also contribute to a new understanding of leukemic cell origin and pathway, which may enable us to overcome the limitations of present classification schemes.
本文回顾了急性淋巴细胞白血病的染色体分析结果。重点讨论了所谓的特异性易位及其与细胞学、免疫学和预后的关系。目前可得的数据表明，急性淋巴细胞白血病中的染色体不仅是一个重要的独立预后因素，而且有助于对白血病细胞起源和途径形成新的认识，这可能使我们能够克服现有分类方案的局限性。
