The Outpatient Ward of Neuropsychiatry, Turku University Central Hospital, Turku, Finland.
Dement Geriatr Cogn Disord. 2013;35(5-6):249-55. doi: 10.1159/000347129. Epub 2013 Mar 7.
Neuropsychiatric symptoms and impairment in performing activities of daily living (ADL) in patients with Parkinson's disease (PD) are strong predictors of the overall caregiver burden and they increase the risk for nursing home admission of the patients. The purpose of the present study was to assess the association of neuropsychiatric symptoms and ADL functions in PD.
A total of 73 community-dwelling PD patients were studied. The mean age of the patient group was 65 years and the mean disease duration was 9 years. The Neuropsychiatric Inventory was used to measure neuropsychiatric symptoms, and ADL abilities were measured by the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory.
The prevalence of neuropsychiatric symptoms in patients with PD was 73%. The most common symptoms were depression, anxiety, irritability, apathy and agitation. ADL ability correlated significantly with apathy (p < 0.002) even when adjusted for motor symptoms.
Apathy was significantly associated with ADL in PD. The result indicates that more attention should be paid to identifying apathy and targeting therapeutic interventions.
帕金森病（PD）患者的神经精神症状和日常生活活动（ADL）受损是整体照顾者负担的强烈预测因素，并且增加了患者入住疗养院的风险。本研究的目的是评估 PD 患者的神经精神症状与 ADL 功能之间的关系。
共研究了 73 名居住在社区中的 PD 患者。患者组的平均年龄为 65 岁，平均病程为 9 年。使用神经精神疾病问卷来测量神经精神症状，使用阿尔茨海默病合作研究-日常生活活动量表来测量 ADL 能力。
PD 患者的神经精神症状患病率为 73%。最常见的症状是抑郁、焦虑、易怒、冷漠和激越。即使在调整运动症状后，ADL 能力与冷漠也显著相关（p<0.002）。
冷漠与 PD 中的 ADL 显著相关。结果表明，应更加关注识别冷漠并针对治疗干预措施。
