Kurosawa H, Matsubayashi S, Ishii Y, Ishida H, Hirasawa Y, Mori Y, Shimada T, Kawakami K
Department of Clinical Laboratory, Jikei University School of Medicine, Tokyo, Japan.
Kaku Igaku. 1990 Feb;27(2):125-31.
A new inhalation technique of 81mKr gas was applied to evaluate the pathophysiological abnormality of ventilation. 81mKr gas (370 MBq) was continuously supplied into a mouth piece directly (without dead space), VE, or through a dead space of 500 ml, VL, in 110 subjects with various lung diseases. Subjects were divided in four groups by a combination of distribution patterns of 81mKr gas obtained by these two inhalation techniques. Group 1: No ventilatory defect in both techniques. Group 2: Defects larger in VE than VL. Group 3: Defects larger in VL than VE. Group 4: No remarkable difference in defects in both techniques. Cases of group 1 were normal in pulmonary function test and chest X-ray. Finding of group 2 reflects early airway closure. This group consisted of cases in remission of bronchial asthma, small air way disease and pulmonary congestion. In group 3, restrictive disease and obstructive disease, especially emphysema, were included. Patients with severe obstructive disease and organized change of pulmonary parenchyma were belonged in group 4. In ventilation study with 81mKr gas, a combined study of inhalation technique through a dead space and by direct infusion may be useful to evaluate a pathophysiological change of various pulmonary diseases.
应用一种新的81mKr气体吸入技术来评估通气的病理生理异常。在110例患有各种肺部疾病的受试者中，将81mKr气体（370MBq）直接（无死腔）、VE或通过500ml死腔、VL持续供应到咬嘴中。根据这两种吸入技术获得的81mKr气体分布模式的组合，将受试者分为四组。第1组：两种技术均无通气缺陷。第2组：VE中的缺陷大于VL。第3组：VL中的缺陷大于VE。第4组：两种技术的缺陷无显著差异。第1组病例的肺功能测试和胸部X光检查正常。第2组的结果反映了早期气道关闭。该组包括支气管哮喘缓解期、小气道疾病和肺充血的病例。第3组包括限制性疾病和阻塞性疾病，尤其是肺气肿。患有严重阻塞性疾病和肺实质机化改变的患者属于第4组。在使用81mKr气体进行通气研究时，通过死腔和直接注入的吸入技术联合研究可能有助于评估各种肺部疾病的病理生理变化。
