Wang Kun, Zhu Huili, Meng Zhiqiang, Chen Zhen, Lin Junhua, Shen Yehua, Gao Huifeng
Department of Integrated Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Onkologie. 2013;36(3):88-92. doi: 10.1159/000348530. Epub 2013 Feb 25.
This study was performed to analyze the safety of high-intensity focused ultrasound (HIFU) for treating pancreatic cancer.
224 cases with advanced pancreatic cancer were enrolled into this study. Real-time sonographic images were taken, and vital signs, liver and kidney function, skin burns, local reactions, and systemic effects were monitored and recorded before, during, and after HIFU. Computed tomography or magnetic resonance imaging (MRI) was also performed before and after HIFU.
Serum amylase level increased in 16 cases (7.1%) 1 day after HIFU treatment, and 9 of these cases also had abnormal urinary amylase levels. Gastrointestinal (GI) dysfunction such as abdominal distension and anorexia with slight nausea was observed in 10 cases (4.5%) after HIFU treatment. 1 case with pancreatic head cancer developed obstructive jaundice 2 weeks after HIFU treatment. Vertebral injury, identified by MRI, occurred in 2 cases, although no symptoms were seen. No severe complications such as skin burns, lesion bleeding, GI tract bleeding or GI perforation were observed in any of the cases.
For specific patients, HIFU treatment is a safe, non-invasive treatment for pancreatic cancer but requires careful preoperative preparation and exact operative performance.
本研究旨在分析高强度聚焦超声（HIFU）治疗胰腺癌的安全性。
224例晚期胰腺癌患者纳入本研究。在HIFU治疗前、治疗期间和治疗后采集实时超声图像，并监测和记录生命体征、肝肾功能、皮肤烧伤、局部反应和全身影响。HIFU治疗前后还进行了计算机断层扫描或磁共振成像（MRI）检查。
16例（7.1%）患者在HIFU治疗后1天血清淀粉酶水平升高，其中9例患者尿淀粉酶水平也异常。10例（4.5%）患者在HIFU治疗后出现腹胀、厌食伴轻度恶心等胃肠功能障碍。1例胰头癌患者在HIFU治疗后2周出现梗阻性黄疸。MRI检查发现2例患者发生椎体损伤，但无相关症状。所有病例均未观察到皮肤烧伤、病灶出血、消化道出血或消化道穿孔等严重并发症。
对于特定患者，HIFU治疗是一种安全、无创的胰腺癌治疗方法，但需要仔细的术前准备和精确的手术操作。
