Mouratidis Petros X E, Ter Haar Gail
Department of Physics, Division of Radiotherapy and Imaging, The Institute of Cancer Research: Royal Marsden Hospital, Sutton, London SM25NG, UK.
Cancers (Basel). 2022 Jan 27;14(3):638. doi: 10.3390/cancers14030638.
Traditional oncological interventions have failed to improve survival for pancreatic cancer patients significantly. Novel treatment modalities able to release cancer-specific antigens, render immunologically "cold" pancreatic tumours "hot" and disrupt or reprogram the pancreatic tumour microenvironment are thus urgently needed. Therapeutic focused ultrasound exerts thermal and mechanical effects on tissue, killing cancer cells and inducing an anti-cancer immune response. The most important advances in therapeutic focused ultrasound use for initiation and augmentation of the cancer immunity cycle against pancreatic cancer are described. We provide a comprehensive review of the use of therapeutic focused ultrasound for the treatment of pancreatic cancer patients and describe recent studies that have shown an ultrasound-induced anti-cancer immune response in several tumour models. Published studies that have investigated the immunological effects of therapeutic focused ultrasound in pancreatic cancer are described. This article shows that therapeutic focused ultrasound has been deemed to be a safe technique for treating pancreatic cancer patients, providing pain relief and improving survival rates in pancreatic cancer patients. Promotion of an immune response in the clinic and sensitisation of tumours to the effects of immunotherapy in preclinical models of pancreatic cancer is shown, making it a promising candidate for use in the clinic.
传统的肿瘤学干预措施未能显著提高胰腺癌患者的生存率。因此，迫切需要能够释放癌症特异性抗原、使免疫“冷”的胰腺肿瘤变“热”并破坏或重新编程胰腺肿瘤微环境的新型治疗方式。治疗性聚焦超声对组织产生热效应和机械效应，杀死癌细胞并诱导抗癌免疫反应。本文描述了治疗性聚焦超声在启动和增强针对胰腺癌的癌症免疫循环方面最重要的进展。我们全面综述了治疗性聚焦超声在治疗胰腺癌患者中的应用，并描述了最近在多个肿瘤模型中显示超声诱导抗癌免疫反应的研究。本文还介绍了已发表的关于治疗性聚焦超声在胰腺癌中的免疫效应的研究。本文表明，治疗性聚焦超声被认为是治疗胰腺癌患者的一种安全技术，可缓解疼痛并提高胰腺癌患者的生存率。本文显示了在临床中促进免疫反应以及在胰腺癌临床前模型中使肿瘤对免疫治疗的效果敏感，使其成为临床上有前景的候选治疗方法。
