Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA.
J Neurosci. 2013 Mar 13;33(11):5017-26. doi: 10.1523/JNEUROSCI.3459-12.2013.
The ability to direct our thought processes influences not only what we do, but also what we remember later. Here we sought to identify the brain network that supports the ability to control memory retrieval and to understand the neural basis of age-related changes and individual differences in the capacity for mnemonic control. To this end, we collected functional MRI data from 43 children and young adults while they attempted to retrieve or suppress retrieval of previously learned associations. Seed-based functional connectivity analyses revealed a largely right-lateralized dorsolateral prefrontal cortex-cingulate-parietal-hippocampal network that exhibited strongly correlated activity during retrieval suppression. Regardless of age, individuals who were able to suppress memory retrieval exhibited tighter coupling between key nodes in this dorsolateral prefrontal cortex-cingulate-parietal-hippocampal network than individuals who did not. Further, only those capable of mnemonic control exhibited tighter coupling during successful retrieval suppression (intentional forgetting) than during unsuccessful retrieval (unintentional forgetting). Across both children and adults, individual differences in retrieval suppression were best explained by the strength of these network interactions.
我们的思维过程具有导向能力，不仅影响我们的行为，还影响我们之后的记忆。在此，我们试图确定支持记忆检索控制能力的大脑网络，并了解与年龄相关的变化和记忆控制能力的个体差异的神经基础。为此，我们收集了 43 名儿童和年轻人的功能磁共振成像数据，在他们尝试检索或抑制先前学习的联想时进行数据收集。基于种子的功能连接分析显示，在检索抑制过程中，右外侧前额叶皮层-扣带回-顶叶-海马网络表现出强烈的相关活动，主要呈右侧偏侧化。无论年龄大小，能够抑制记忆检索的个体在这个外侧前额叶皮层-扣带回-顶叶-海马网络的关键节点之间表现出更紧密的耦合，而不能抑制记忆检索的个体则没有。此外，只有那些具有记忆控制能力的个体在成功的检索抑制（有意遗忘）期间表现出比不成功的检索（无意遗忘）更紧密的耦合。在儿童和成年人中，检索抑制的个体差异可以通过这些网络相互作用的强度来很好地解释。
