Institute of Motor Control and Movement Technique, German Sport University Cologne, Cologne, Germany.
J Hum Kinet. 2011 Dec;30:59-63. doi: 10.2478/v10078-011-0073-2. Epub 2011 Dec 25.
The calcium-binding protein S100B is produced primarily by astrocytes and exerts concentration-dependent paracrine and autocrine effects on neurons and glia. The numerous findings of a correlation between S100B and traumatic brain injury (TBI) have resulted in the employment of this protein as a clinical biomarker for such injury. Our present aim was to determine whether cycling with (V) or without (NV) vibration alters serum concentrations of S100B. Twelve healthy, male non-smokers (age: 25.3±1.6 yrs, body mass: 74.2±5.9 kg, body height: 181.0±3.7 cm, VO2peak: 56.9±5.1 ml·min(-1)·kg(-1) (means ± SD)) completed in random order two separate trials to exhaustion on a vibrating bicycle (amplitude 4 mm and frequency 20 Hz) connected to an ergometer. The initial workload of 100 W was elevated by 50 W every 5 min and the mean maximal period of exercise was 25:27±1:30 min. The S100B in venous blood taken at rest, immediately after the test, and 30, 60 and 240 min post-exercise exhibited no significant differences (p>0.05), suggesting that cycling with and without vibration does not influence this parameter.
钙结合蛋白 S100B 主要由星形胶质细胞产生，并对神经元和神经胶质细胞发挥浓度依赖性旁分泌和自分泌作用。大量研究发现 S100B 与创伤性脑损伤（TBI）之间存在相关性，这导致该蛋白被用作此类损伤的临床生物标志物。我们目前的目的是确定振动（V）或不振动（NV）是否会改变血清 S100B 浓度。12 名健康的男性非吸烟者（年龄：25.3±1.6 岁，体重：74.2±5.9 公斤，身高：181.0±3.7 厘米，峰值摄氧量：56.9±5.1 ml·min(-1)·kg(-1)（平均值±标准差））以随机顺序完成了两次单独的振动自行车（振幅 4 毫米，频率 20 Hz）与测功计相连的疲劳试验。初始工作负荷为 100 W，每 5 分钟增加 50 W，平均最大运动时间为 25:27±1:30 分钟。在休息时、测试后立即以及运动后 30、60 和 240 分钟采集的静脉血中的 S100B 没有显著差异（p>0.05），这表明振动和不振动对该参数没有影响。
