Marchi Nicola, Cavaglia Marco, Fazio Vincent, Bhudia Sunil, Hallene Kerri, Janigro Damir
Department of Neurological Surgery, Cerebrovascular Research Center, NB20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Clin Chim Acta. 2004 Apr;342(1-2):1-12. doi: 10.1016/j.cccn.2003.12.008.
Neurological diseases are often associated with cerebrovascular dysfunction and changes in blood-brain barrier (BBB) function. This is important for two seemingly conflicting reasons. On the one hand, a leaky BBB may lead to brain disease by allowing extravasation of cells and molecules normally segregated in the periphery, while on the other hand an intact BBB may hamper drug delivery to the ailing brain. Under both circumstances, it would be desirable to follow closely over time BBB "tightness". Several lines of evidence have suggested that the astrocytic protein S100beta is a potentially useful peripheral marker of BBB permeability. Other markers of brain-to-blood barriers have been recently discovered by a proteomic approach. These proteins are virtually absent in normal blood, appear in serum from patients with cerebral lesions, and can be easily detected. We will present clinical and laboratory evidence supporting the use of these markers as modern neurodiagnostic tools.
神经疾病常与脑血管功能障碍及血脑屏障（BBB）功能变化相关。这一点很重要，原因看似相互矛盾。一方面，血脑屏障渗漏可能会因允许通常隔离在外周的细胞和分子外渗而导致脑部疾病，而另一方面，完整的血脑屏障可能会阻碍药物输送到患病的大脑。在这两种情况下，都希望长期密切跟踪血脑屏障的“紧密性”。有几条证据表明，星形胶质细胞蛋白S100β是血脑屏障通透性潜在有用的外周标志物。最近通过蛋白质组学方法发现了其他脑-血屏障标志物。这些蛋白质在正常血液中几乎不存在，出现在脑部病变患者的血清中，并且易于检测。我们将展示支持使用这些标志物作为现代神经诊断工具的临床和实验室证据。
