氧手性甘油引发的不对称自催化反应。
Asymmetric autocatalysis triggered by oxygen isotopically chiral glycerin.
机构信息
Department of Applied Chemistry, Tokyo University of Science, Kagurazaka, Tokyo, 162-8601, Japan.
出版信息
Org Biomol Chem. 2013 May 14;11(18):2928-31. doi: 10.1039/c3ob40293b.
PMID:23487262
Abstract
Chiral (S)- and (R)-(18)O-glycerin induces enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde, and the subsequent asymmetric autocatalysis affords (R)- and (S)-pyrimidyl alkanol with high enantiomeric excess, respectively.
摘要
手性 (S)- 和 (R)-(18)O-甘油诱导二异丙基锌对嘧啶-5-甲醛的对映选择性加成，随后的不对称自催化分别得到 (R)-和 (S)-嘧啶基烷醇，具有高对映过量。
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