非对称自催化作用作为手性起源与高对映富集化合物之间的有效连接。
Asymmetric Autocatalysis as an Efficient Link Between the Origin of Homochirality and Highly Enantioenriched Compounds.
机构信息
Department of Applied Chemistry, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan.
Research Organization for Nano & Life Innovation, Waseda University, Wasedatsurumaki-cho, Shinjuku-ku, Tokyo, 162-0041, Japan.
出版信息
Orig Life Evol Biosph. 2022 Sep;52(1-3):57-74. doi: 10.1007/s11084-022-09626-7. Epub 2022 Aug 12.
Biological homochirality of essential components such as L-amino acids and D-sugars is prerequisite for the emergence, evolution and the maintenance of life. Implication of biological homochirality is described. Considerable interest has been focused on the origin and the process leading to the homochirality. Asymmetric autocatalysis with amplification of enantiomeric excess (ee), i.e., the Soai reaction, is capable to link the low ee induced by the proposed origins of chirality such as circularly polarized light and high ee of the organic compound. Absolute asymmetric synthesis without the intervention of any chiral factor was achieved in the Soai reaction.
生物必需成分（如 L-氨基酸和 D-糖）的生物手性是生命出现、进化和维持的前提。本文描述了生物手性的含义。人们对导致手性的起源和过程产生了浓厚的兴趣。具有放大对映体过量（ee）的不对称自催化作用，即 Soai 反应，能够连接由手性起源（如圆偏振光）诱导的低 ee 和有机化合物的高 ee。Soai 反应实现了无需任何手性因素干预的绝对不对称合成。
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